A model of how the sickle-cell gene produces malaria resistance
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منابع مشابه
A model of how the sickle-cell gene produces malaria resistance.
A model of resistance to falciparum malaria provided by the sickle-cell gene in heterozygous state is presented based on earlier hypotheses, the life cycle of P. falciparum within its human host, and the nature of host response. Falciparum populations are reduced in size with each cycle of erythrocytic schizogony in sicklers because many parasitized cells are sequestered, sickled, and phagocyti...
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Sickle cell protection from malaria
A linkage between presence of Sickle Haemoglobin (HbS) and protection from malaria infection and clinical manifestations in certain areas was suspected from early observations and progressively elucidated by more recent studies. Research has confirmed the abovementioned connection, but also clarified how such protection may be abolished by coexistence of sickle cell trait (HbS trait) and alpha ...
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Sickle cell anaemia is a major chapter within haemolytic anaemias; at the same time, its epidemiology is a remarkable signature of the past and present world distribution of Plasmodium falciparum malaria. In this brief review, in keeping with the theme of this journal, we focus on the close and complex relationship betweeen this blood disease and this infectious disease. On one hand, heterozygo...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 1975
ISSN: 0022-5193
DOI: 10.1016/0022-5193(75)90027-2